Meropenem injection is used to treat infections caused by bacteria. We would like to show you a description here but the site wont allow us. Switching to iv push, using solutions other than saline, using large volume solutions, or using syringe infusion pumps, may change the stability and compatibility characteristics of the medication to be. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis. Discard the vial at the notice of any suspended particles. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Meropenem kabi 500 mg powder for solution for injection or infusion 20 ml glass vials and 100 ml colourless glass bottles, closed with bromobutilic rubber stopper and sealed with aluminium caps. Learn about the prescription drug meropenem merrem used to treat a variety of bacterial infections. Get meropenem injection at best price with product specifications.
There is no accumulation of repeated doses of meropenem 500 mg every 8 hours, or 1 gram every 6 hours in patients with normal renal function. Meropenem is boadly active against resistant enteric gramnegative rods and. However, meropenem and doripenem are less active against e. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes see section 6. This medication is good for only 5 days after mixing when stored in the refrigerator and protected from light. Following intravenous administration, meropenem auc, clr, and total. Merrem iv meropenem is an antibiotic used to treat certain types of bacterial infections.
Cosmetic act fdca for merrem meropenem for injection iv. Find out what health conditions may be a health risk when taken with meropenem intravenous. Trissel, this tool provides clinicians with access to the information they. Meropenem undergoes both filtration and tubular secretion. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes alternatively, doses. This prior approval supplemental new drug application provides for labeling changes to dosage and administration section, use in adult patients with renal impairment 2. Merrem iv meropenem dosing, indications, interactions. Meropenem prices, coupons and patient assistance programs. This medicine will not work for colds, flu, or other virus infections this medicine is to be given only by or under the direct supervision of your doctor. Reconstitute a 1 g vial according to manufacturer recommendations. Meropenem injection is a prescription medicine that is used to treat certain infections including complicated skin and soft tissue infection, complicated stomach cavity infection, infection during or following childbirth, urinary tract infection, and lower respiratory tract infection in patients with damaged lungs and digestive system. Meropenem definition of meropenem by medical dictionary.
The dry powder should be stored at controlled room temperature 2025. Meropenem iv 1grambag sd 50ml 24 bagscase hazardous. Meropenem 1g powder for solution for injectioninfusion summary of product characteristics. Monographs for commonly administered intravenous medications in home and community care 2 p a g e meropenem administration2,4,5 can be dispensed as single doses and administered by gravity or pole pump with each nursing visit. Meropenem has not been fdaapproved for administration as a continuous intravenous infusion. Solutions prepared for infusion meropenem concentrations ranging from 1 mgml to 20 mgml re. Five of the 6 cases of skin and soft tissue infections were cured or improved with meropenem therapy. However, it is your obligation to verify such information before using the products purchased from mcguff. The iv ld50 of meropenem in rodents is greater than 2000 mgkg.
Medication errors in intravenous drug preparation and. Patient was educated on how to take meropenem intravenous as follows. Meropenem, sold under the brandname merrem among others, is a broadspectrum antibiotic used to treat a variety of bacterial infections. Meronem iv 500mg summary of product characteristics. Meropenem is a recently developed carbapenem antibiotic, similar to imipenem, with a wide spectrum of activity against grampositive and gramnegative bacteria. All of the above materials were used without further purification. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and. Dailymed meropenem meropenem injection, powder, for. Merrem meropenem is only available as an injectable, so its usually only given for serious infections. Look up information on diseases, tests, and procedures. The medicinal product is supplied in pack sizes of 1 or 10 vialsbottles. Skin and soft tissue infections sstis are very frequently encountered in clinical. Intermittent an infusion from a burette or minibag running over approximately 1560 minutes.
Find patient medical information for meropenem intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase i dhpi, thus precluding the need for coadministration with an inhibitor of dhpi, such as cilastatin. Adenosine rapid iv bolus given by a doctor or under direct supervision 2 seconds can be diluted with ns compatibility with other. Dailymed meropenem injection, powder, for solution. The usual dose is 500 mg to 1 g by intravenous infusion every 8 hours, depending on.
Tdmmonograph meropenem october 2015, concept version page 2 of 5 caused by pseudomonas aeruginosa. At the end of a 30 minute intravenous infusion of a single dose of meropenem for injection iv in healthy. Merrem iv meropenem for injection, for intravenous use. Generic brand, astrazeneca, intravenous iv meropenem was reconstituted with 20 ml water for injection and further diluted with 50 ml of 0. Meropenem novaplus, merrem iv, premierpro rx meropenem there may be other brand names for this medicine. Know meropenem 500 mg injection uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions. A nebulizer delivery system consists of a nebulizer small plastic medication cup with a lid that drops into the cup and twists and a. The king guide to parenteral admixtures is designed to help practitioners decide which alternative administration strategy is best. Meropenem is a member of the carbapenems drug class and is commonly used for intraabdominal infection, meningitis, nosocomial pneumonia, and others. Assay preparation 1 where it is represented as being a singledose container constitute a container of meropenem for injection with a volume of water, accurately measured, corresponding to the amount of solvent specified in the labeling. Meropenem injection comes as a powder to be mixed with liquid and injected intravenously into a vein. Meropenem injection, meropenem injection manufacturers. Do not mix other injectable medications in the same iv bag or tubing with meropenem. Meropenem 1 g powder for solution for injection or infusion.
The iv ld 50 of meropenem in rodents is greater than 2000 mgkg. Meropenem 500 mg injection is a broad spectrum antibiotic used to treat a variety of conditions caused by bacteria such as infections of stomach, brain, and lungs. Administer as iv infusion over about 15 to 30 minutes or as an iv bolus injection over about 3 to 5 minutes. Intravenous injection introduced directly into a vein or a freely flowing iv line. Continuous an infusion running over more than 1 hour. The solutions should be inspected visually for particles and discolouration prior. Withdraw all of the withdrawable contents, using a suitable hypodermic needle and syringe, and transfer to a 100ml volumetric flask. Meronem iv 500mg summary of product characteristics smpc. When constituted as instructed see dosage and administration. Find patient medical information for meropenem in 0. Infectious diseases merck manuals professional edition. Meropenem for injection is indicated as a single agent therapy for the treatment of bacterial meningitis caused by streptococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis.
Meropenem 500 mg powder for solution for injection or infusion emc. Critical care intravenous drug administration guide. Inhaled methods deliver medication directly to the airway, which is useful for respiratory problems. Most enterococcus faecalis and many pseudomonas aeruginosa strains, including those resistant to broadspectrum penicillins and cephalosporins, are susceptible to imipenem, meropenem, and doripenem but are resistant to ertapenem. Meropenem 500 mg injection uses, dosage, side effects. Meropenem side effects, dosage, interactions drugs. Meropenem 1g powder for solution for injectioninfusion. Also, discard the vial, if contents are cloudy or discolored or if the. Medication errors in intravenous drug preparation and administration med j malaysia vol 68 no 1 february 20. Merrem iv is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Meropenem merrem, meronem is a broadspectrum antibacterial agent of the carbapenem family, indicated as empirical therapy prior to the identification of causative organisms, or for disease caused by single or multiple susceptible bacteria in both adults and.
Based upon the trusted trissels 2 clinical pharmaceutics database by lawrence a. Medication errors in intravenous drug preparation and administration med j malaysia vol 68 no 1 february 20 53. Mcguff work very hard to provide you accurate and timely information on our website. Prepare your injection only when you are ready to give it. Merrem meropenem is an antibiotic thats usually only given in the hospital for serious infections. List item meronem article 30 referral annex i, ii, iii european. Meropenem reconstitution instructions 500 mg vial your pet was prescribed meropenem, a liquid intravenous antibiotic for infections. Meropenem for injection, usp is a sterile, pyrogenfree, synthetic, carbapenem antibacterial for intravenous administration. Make sure the medication is clear and free of any suspended particles, before use. You should not receive it if you had an allergic reaction to meropenem or other antibiotics, including penicillins or. Single dose minibags can be infused over 1530 minutes. Meropenem by injection national library of medicine. A regimen of 500mg iv q6h is able to achieve a similar probability of target attainment with. Compare prices, print coupons and get savings tips for meropenem generic merrem and other skin infection, bacterial infection, meningitis, and gastrointestinal infection drugs at cvs, walgreens, and other pharmacies.
Meropenem fda prescribing information, side effects and uses. Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes see sections 6. Meropenem also treats pneumonia and inflammation of the. Standard aseptic techniques should be used for solution preparation and administration. The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin non. The length of treatment depends on your general health, the type of infection you have, and how well you respond to the medication. This is a demonstration of how to prepare and administer meropenem using an aseptic nontouch technique antt. It should be used with caution in patients with central nervous system disorders. By continuing to browse this site you are agreeing to our use of cookies. Meropenem in the treatment of complicated skin and soft tissue. Administer by iv infusion over about 15 to 30 minutes. Pharmaceutical dosages from meropenem infusion vials mg were prepared in a fume hood using an aseptic, nontouch technique.
How to take meropenem intravenous home health patient. It works by killing the bacteria or preventing their growth. It can be given at home, but youll have to be taught how to inject it correctly. Helps to improve outcomes by verifying iv drug compatibility verifies drug compatibility and stability trissels iv chek api is an electronic tool that verifies the compatibility and stability of parenteral medications. Meronem iv 500mg powder for solution for injection or infusion emc. An investigation of the stability of meropenem in elastomeric infusion.
Approximately 70% 50% to 75% of a meropenem dose administered intravenously is recovered unchanged in the urine over 12 hours 1. You should not receive it if you had an allergic reaction to meropenem or other antibiotics, including penicillins or cephalosporins. Meropenem 500 mg powder for solution for injection or infusion. Program and abstracts of the 18th int congr chemother, stockholm 27.
Traditional intermittent infusion method over 30 minutes. Using a pari lc plus nebulizer with meropenem many medications are available as inhaled treatments. Available online through esupply using arup connect or contact arup client services at 800 5222787. Meronem iv 500mg powder for solution for injection or infusion summary of product characteristics smpc by. Webmd provides common contraindications for meropenem intravenous.